Comparative transcriptomic meta-analysis reveals elevated TCL1A expression in human circulating immune cells across chronic pain conditions
Authors' conclusion
Through transcriptomic meta-analysis of open-access data, we identified genes conserved across pain conditions and uncovered sex-specific signatures, including increased expression of TCL1A as a potential biomarker for neuropathic pain in a subset of women.
Study context
- Population
- Circulating immune cells of patients with chronic pain across six chronic pain conditions and control subjectssix chronic pain conditions
- Participants
- 142 vs 154
- Comparison
- Chronic pain vs control subjects
- Chronic painn = 142
- Controlsn = 154reference
- Outcome
- Differentially expressed genes in chronic pain
Methodological detailsreprocessed bulk RNA-sequencing studies, sex-stratified analysis, protein-level validation in an independent cohort
- Reprocessed bulk RNA-sequencing studies
- Sex-stratified analysis
- Protein-level validation in an independent cohort
Pooled result
As reported in the abstract
- Genes differentially expressed, combined-sex analysis
- 19
- Genes altered in women (sex-stratified), including TCL1A
- 34
- TCL1A expression correlated with neuropathic symptom severity
- P<0.05
Further pooled results
Protein-level validation, independent cohort
- Findings confirmed in women with neuropathic pain
Original publication
Comparative transcriptomic meta-analysis reveals elevated TCL1A expression in human circulating immune cells across chronic pain conditions. Br J Anaesth. Published 7 November 2025. doi:10.
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