A Comparison of Long-Term Outcomes in Patients Managed With Venovenous Extracorporeal Membrane Oxygenation in the First and Second Waves of the COVID-19 Pandemic in the United Kingdom
Main finding · Survival at censoring date and decannulationResult — go to the resultχ 2 6.35Authors' conclusion
Most patients with COVID-19 supported on ECMO in both waves survived in the short and longer term. At follow-up patients had similar lung function and QOL across the two waves.
Study context
- Population
- Patients supported on venovenous extracorporeal membrane oxygenation (ECMO) for COVID-19 in a severe acute respiratory failure service, UKincluded in analysis
- Participants
- 123 patients
- Exposure
- COVID-19 wave 2 vs wave 1 patients supported on venovenous ECMO
- Outcome
- Survival at censoring date and decannulation
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
χ 2
6.35
P = 0.012
- Survival at decannulation significantly lower in wave 2 (90.4% vs 70.0%)
- P < 0.001
Observational data: associations, not effects.
Further findings
Duration of ECMO run · longer in wave 2
P = 0.005
Factors independently associated with increased mortality
| OR (CI) | P value | ||
|---|---|---|---|
| Age | 1.07 (1.01–1.14) | P = 0.025 | |
| NIV use | 3.37 (1.12–12.60) | P = 0.043 | |
| 0.050.21520Odds ratio (log scale) |
Noninvasive ventilation (NIV) before ECMO
- Longer NIV application prior to ECMO in wave 2
QOL and lung function · first follow-up
- Similar across waves, apart from transfer coefficient of carbon monoxide corrected for hemoglobin
Safety
- Higher frequency of barotrauma in wave 2
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A Comparison of Long-Term Outcomes in Patients Managed With Venovenous Extracorporeal Membrane Oxygenation in the First and Second Waves of the COVID-19 Pandemic in the United Kingdom. Crit Care Med. Published 5 April 2023. doi:10.
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