Comparison of remimazolam tosylate and sevoflurane for anesthesia induction with preserved spontaneous respiration during tracheal intubation: a prospective, single-center, randomized controlled trial
Authors' conclusion
Compared with sevoflurane, remimazolam can be safely and effectively used for intubation while preserving spontaneous breathing, with a shorter time to achieve conditions for topical anesthesia and intubation.
Study context
- Population
- Patients aged 18–65 years with non-difficult airways scheduled for endotracheal intubation under GA
- Participants
- 30 vs 30
- Comparison
- Remimazolam vs Sevoflurane
- Remimazolamn = 30
- Sevofluranen = 30reference
- Primary endpoint
- Feasibility and safety of induction with preserved spontaneous respiration (successful anaesthesia induction intubation)
Methodological detailsprospective, single-centre
- Prospective
- Single-centre
Primary result
As reported in the abstract
Successful anaesthesia induction intubation
- All enrolled patients successfully intubated
- Success: no rescue measures, no awakening, spontaneous breathing preserved throughout, intubation completed
Further findings
Time to achieve condition for topical anaesthesia to the throat
P < 0.01
Total time to complete intubation
P < 0.01
HR, BP, oxygen saturation, blood gas results
- No statistically significant differences between the groups
Safety
Coughing during local anaesthetic throat spray
Continued coughing during intubation
Severe respiratory depression or other complications
- None observed in either group
Coughing during local anaesthetic throat spray
- Difference statistically significant
Continued coughing during intubation
- Difference not statistically significant
Original publication
Comparison of remimazolam tosylate and sevoflurane for anesthesia induction with preserved spontaneous respiration during tracheal intubation: a prospective, single-center, randomized controlled trial. Perioper Med (Lond). Published 1 October 2025. doi:10.
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