Complications leading to device explant in patients with chronic non-cancer pain receiving intrathecal drug delivery
Authors' conclusion
Device-related infections are the leading cause for explants in IDD for chronic non-cancer pain. Explants due to loss of analgesic efficacy occurred at a lesser frequency with IDD compared with SCS explants in a similar patient population.
Study context
- Population
- Patients with chronic non-cancer pain (majority PSPS2) who underwent intrathecal drug delivery device implant by Pain Medicine physicians, June 2009–December 2022184 with PSPS2
- Participants
- 215 patients
- Outcome
- Complications leading to device explant
Methodological detailssingle tertiary academic centre
- Single tertiary academic centre
Main finding
As reported in the abstract
Explant rate
26.1%
Device-related infection (leading cause of explant), % of patients
9.3%
Device-related infection, % of device surgeries
5.9%
Loss of analgesic efficacy leading to explant, % of patients
5.6%
Observational data: associations, not effects.
Further findings
Loss of analgesic efficacy vs spinal cord stimulation (SCS) habituation explants
- Significantly less than explant rate due to habituation with SCS in a similar population
Time from implant to explant
- Much earlier interval for infections than for other complications
Predictors of explant
- No demographic or comorbidity factors correlated with explants
Safety
Device-related infection
- % of patients
- 9.3%
- % of device surgeries
- 5.9%
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →