Cardiac arrest & resuscitation
Computed tomography grey-white matter ratio at the basal ganglia level in a reference population for hypoxic ischaemic encephalopathy after cardiac arrest – A cross-sectional observational study
Authors' conclusion
A GWR at the basal ganglia level below 1.10 is very unlikely in elderly patients without HIE
Study context
- Population
- Patients with computed tomography (CT) for suspected stroke or transient ischaemic attack, matched for age and sex to cardiac arrest populations, without pathologic CT findings
- Participants
- 155 patients
- Outcome
- GWR < 1.10 at the basal ganglia level on head CT
Methodological detailsretrospective, single-centre, Three raters placed circular regions of interest (ROIs) of 0.1 and 0.2 cm² at the basal ganglia level
- Retrospective
- Single-centre
- Three raters placed circular ROIs of 0.1 and 0.2 cm² at the basal ganglia level
Main finding
As reported in the abstract
GWR < 1.10
- No measurement resulted in GWR < 1.10
Observational data: associations, not effects.
Further findings
Median GWR for all raters
- 0.1 cm² ROIs, range of medians
- 1.30-1.32
- 0.2 cm² ROIs, range of medians
- 1.27-1.32
Interrater agreement (Bland-Altman)
- Lower and upper limits of agreement between raters around
- 0.1
- 0.2 cm² ROIs achieved smaller limits of agreement than 0.1 cm² ROIs
- Attenuation measurements and GWR differed depending on ROI size
Original publication
Computed tomography grey-white matter ratio at the basal ganglia level in a reference population for hypoxic ischaemic encephalopathy after cardiac arrest – A cross-sectional observational study. Resuscitation. Published 4 July 2025. doi:10.
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