Pediatric anesthesia & critical care
Continuous infusion of beta-lactam antibiotics in pediatric intensive care unit: A monocenter before/after implementation study
Authors' conclusion
Protocolization of Beta-lactam continuous infusion was associated with more frequent target concentration achievements in PICU.
Study context
- Population
- PICU patients with beta-lactam treatment for more than 2 days and at least one therapeutic drug monitoring (TDM) sample214 and 199 assays
- Participants
- 72 vs 103
- Exposure
- P2 vs P1
- P2n = 72
- P1n = 103reference
- Outcome
- Target concentration achievement (fT>4× Minimum Inhibitory Concentration = 100%)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Target concentration achievement
P < 0.001
Observational data: associations, not effects.
Further findings
C-reactive protein · Day 5/6 after beta-lactam initiation
P < 0.05
Daily average reconstitution time of beta-lactam syringes per child
P < 0.001
| Outcome | P1 | P2 | P value |
|---|---|---|---|
| Daily average cost of beta-lactam vial consumption per child | 5.04 ± 2.6 | 3.21 ± 2.7 | P < 0.001 |
Factors associated with target achievement (multivariable logistic regression)
- P2, BSA and albumin positively associated; urea and male sex negatively associated
Original publication
Continuous infusion of beta-lactam antibiotics in pediatric intensive care unit: A monocenter before/after implementation study. Anaesth Crit Care Pain Med. Published 13 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →