Critical care admissions and outcomes in pregnant and postpartum women: a systematic review
Authors' conclusion
Mortality for critically ill peripartum women is substantial and the gap in reported ICU admissions and mortality for critically ill peripartum women between HIC and LMICs remains unacceptably high.
Study context
- Population
- Pregnant and postpartum women admitted to ICU
- Participants
- 111,601 participants · 71 studies
- Comparison
- High-income countries (HICs) vs low-middle-income countries (LMICs)
- Outcome
- ICU admission rate and ICU mortality
Methodological detailsmultivariable meta-regression, mixed-effects models, 56 studies retrospective; case definitions, admission criteria and causes of mortality heterogeneous
- Multivariable meta-regression
- Mixed-effects models
- 56 studies retrospective; case definitions, admission criteria and causes of mortality heterogeneous
Pooled result
As reported in the abstract
ICU admission rate
ICU admission rate HICs 0.4% (95% CI 0.32–0.48) · LMICs 2.8% (95% CI 0.65–6.4)
I2
- LMICs vs HICs: P < 0.0001
- Pooled ICU admission rate
- 1.6% (95% CI 1.28-1.99; I2 = 99.8%)
- Meta-regression: ICU admission rate associated with geographic region (HIC vs LMIC)
- P = 0.0001
Further pooled results
ICU mortality HICs 1.4% (95% CI 0.8–2.1) · LMICs 12.4% (95% CI 8.1–17.5) · P < 0.0001
I2
- ICU mortality — Pooled ICU mortality, 140,780 admissions in 63 studies
- 6.5% (95% CI 5.2-7.9; I2 = 98.7%)
- ICU mortality — Meta-regression: mortality associated with geographic region (HIC vs LMIC)
- p = 0.0003
Change since Pollock et al. 2010 review
- Reported studies, 71 vs 40
- Reported admissions, 111,601 vs 7887, particularly from LMICs
Original publication
Critical care admissions and outcomes in pregnant and postpartum women: a systematic review. Intensive Care Med. Published 28 October 2024. doi:10.
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