Cardiac arrest & resuscitation
Cumulative effect of public health interventions on time interval to first chest compression and survival outcomes in out-of-hospital cardiac arrest
Authors' conclusion
The implementation of cumulative multiple interventions was significantly associated with reduced time to first chest compression and improved OHCA survival outcomes.
Study context
- Population
- Adult, non-traumatic OHCA in Singapore
- Comparison
- Six nationwide interventions vs Pre-intervention
- Primary endpoint
- System-level time interval to first chest compression and survival outcomes
Methodological detailsnationwide, 7 sequential time periods
- Nationwide
- 7 sequential time periods
Primary result
As reported in the abstract
Time to first chest compression and survival
Six nationwide interventions vs Pre-interventionOdds ratio (95 % CI)
Survival to hospital discharge
2.09(1.39–3.14)
Survival with favorable neurological outcomes
3.06(1.79–5.25)
- Time interval to first chest compression
- β-estimate −4.09 (95 % CI −4.81 to −3.37)
- Time to first chest compression, period 1 to 7 (minutes)
- 10.6 (8.5, 13.4), 10.9 (8.8, 13.9), 7.5 (0.0, 11.9), 5.0 (0.0, 12.1), 5.0 (2.4, 11.9), 4.3 (2.0, 10.5) and 4.5 (2.1, 11.3)
Further findings
Mediation by time to first chest compression
%
- Proportion of intervention–survival to discharge relationship explained
- 21.17
- Proportion of intervention–favorable neurological outcome relationship explained
- 22.67
Original publication
Cumulative effect of public health interventions on time interval to first chest compression and survival outcomes in out-of-hospital cardiac arrest. Resuscitation. Published 12 September 2025. doi:10.
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