ICU sedation, delirium & recovery
Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose-associated 90-Day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE III)
Primary result · 90-day mortality, escalating propofol dose at steady dexmedetomidine (younger patients)Result — go to the resultHazard ratio 0.59 95% CI 0.43–0.78Authors' conclusion
In patients ⩽65 years of age sedated with dexmedetomidine and propofol combination, preferentially increasing the dose of propofol was associated with decreased adjusted 90-day mortality.
Study context
- Population
- Critically ill patients randomised in SPICE III to dexmedetomidine and given supplemental propofol
- Participants
- 1,177 patients
- Comparison
- Escalating propofol vs dexmedetomidine infusion rates in combination sedation, stratified by age (>65 vs ⩽65 yr)
- ⩽65 yrn = 598
Methodological detailssecondary cohort analysis, double stratification analysis, multivariable Cox regression
- Secondary cohort analysis
- Double stratification analysis
- Multivariable Cox regression
Primary result
As reported in the abstract
90-day mortality, escalating propofol dose at steady dexmedetomidine (younger patients) · 90 days
Hazard ratio
0.59
95% CI 0.43–0.78
P < 0.0001
Escalating propofol infusion rate
HR 0.59 (95% CI 0.43–0.78); P < 0.0001
Further findings
90-day mortality, escalating dexmedetomidine dose (younger patients)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Escalating dexmedetomidine infusion rateYounger patients; adjusted · multivariable regression | 1.30 (1.03–1.65) | P = 0.029 | |
| 0.512Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose-associated 90-Day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE III). Am J Respir Crit Care Med. Published 1 April 2023. doi:10.
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