Direct oral anticoagulant plasma concentrations according to the time elapsed since the last dose and to renal function: a retrospective study in geriatric patients with hip fractures
Authors' conclusion
Most elderly patients with preserved renal function had plasma DOAC concentrations below 100 ng ml-1 at 24 h.
Study context
- Population
- Patients aged ≥65 years on direct oral anticoagulants (DOACs) admitted for hip fracture after a low-energy traumatic event; inappropriate dosing or contraindications excluded from main analysisanalysed
- Participants
- 186 patients
- Exposure
- Estimated glomerular filtration rate (eGFR) ≥50 vs <50 ml min-1
- eGFR ≥50 ml min-1n = 49reference
- Outcome
- Proportion with plasma DOAC concentration ≥100 ng ml-1
- Follow-up
- 24 h after the last estimated dose
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Plasma DOAC concentration ≥100 ng ml-1 · 24 h
Observational data: associations, not effects.
Further findings
Inappropriate DOAC dosing
- Significantly associated with higher residual plasma concentrations (9 patients excluded)
Original publication
Direct oral anticoagulant plasma concentrations according to the time elapsed since the last dose and to renal function: a retrospective study in geriatric patients with hip fractures. Eur J Anaesthesiol Intensive Care. Published 17 February 2026. doi:10.
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