Perioperative medicine & outcomes
Dose-dependent relationship between intra-procedural hypoxaemia or hypocapnia and postoperative delirium in older patients
Authors' conclusion
Intra-procedural hypoxaemia and hypocapnia were dose-dependently associated with a higher risk of postoperative delirium.
Study context
- Population
- Inpatients ≥60 yr undergoing anaesthesia for surgical or interventional procedures, 2009–2020, academic healthcare network, USA (Massachusetts)42,894 under GA
- Participants
- 71,717 inpatients
- Exposure
- Intra-procedural hypoxaemia or hypocapnia vs none
- Hypoxaemian = 2,532
- Hypocapnian = 532
- Outcome
- Delirium
- Follow-up
- Within 7 days after surgery
Methodological detailshospital registry study, academic healthcare network
- Hospital registry study
- Academic healthcare network
Main finding
As reported in the abstract
Postoperative delirium within 7 days
Adjusted odds ratio (95% CI)P value
Hypoxaemia
1.71(1.40–2.07)
P < 0.001Hypocapnia
1.77(1.30–2.41)
P < 0.001- Postoperative delirium, all patients
- 1702 (2.4%)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Event duration (per minute increase in longest continuous episode)Hypoxaemia · per minute | 1.03 (1.02–1.04) | P < 0.001 | |
| Event duration (per minute increase in longest continuous episode)Hypocapnia · per minute | 1.01 (1.00–1.01) | P = 0.005 | |
| 0.512Adjusted odds ratio (log scale) |
Hypercapnia and postoperative delirium
| aOR (95% CI) | P value | ||
|---|---|---|---|
| HypercapniaNo association | 1.24 (0.90–1.71) | P = 0.181 | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Dose-dependent relationship between intra-procedural hypoxaemia or hypocapnia and postoperative delirium in older patients. Br J Anaesth. Published 1 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →