Neuroanesthesia & neurocritical care
Dynamic driving pressure and clinical outcomes in mechanically ventilated patients with acute brain injury: a secondary analysis of the VENTIBRAIN study*
Primary result · ICU mortality per daily 1cmH2O ΔPdynResult — go to the resultHazard ratio 1.057 95% CrI 1.037–1.078Authors' conclusion
Higher time-varying ΔPdyn was associated with increased mortality in this cohort of patients with ABI.
Study context
- Population
- Mechanically ventilated adults with acute brain injury (TBI, SAH, intracranial hemorrhage or ischemic stroke)
- Participants
- 1,555 participants
- Comparison
- Higher vs lower time-varying dynamic driving pressure
- Primary endpoint
- ICU mortality by time-varying ΔPdyn (peak inspiratory pressure minus PEEP, daily over first 14 days)
Methodological detailsprespecified, Bayesian joint models
- Prespecified
- Bayesian joint models
Primary result
ICU mortality per daily 1cmH2O ΔPdyn
Hazard ratio
1.057
95% CrI 1.037–1.078
ΔPdyn per daily 1cmH2O
HR 1.057 (95% CrI 1.037–1.078)
Per daily 1cmH2O, as printed
As reported in the abstract
Further findings
Acute brain injury (ABI) subtypes and static ΔP (subgroup)
- Consistent across all ABI subtypes; similar for static ΔP (plateau pressure minus positive end-expiratory pressure (PEEP))
Effect modification by Glasgow Coma Scale (GCS) and PaO2/FiO2 (subgroup)
- Association strongest in severe ABI (GCS ≤ 8) and severe hypoxemia (PaO₂/FiO₂ ≤ 100)
Other outcome time points (hospital discharge, 6 months) and sensitivity analyses
- Results robust across all outcome timepoints and multiple sensitivity analyses
Original publication
Dynamic driving pressure and clinical outcomes in mechanically ventilated patients with acute brain injury: a secondary analysis of the VENTIBRAIN study*. Intensive Care Med. Published 15 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →