Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial
Primary result · 24-hour mortalityResult — go to the resultDifference −4.3% 95% CI −12.8% to 3.5%Authors' conclusion
In severely injured patients, early cold stored platelet transfusion is feasible, safe and did not result in a significant lower rate of 24-hour mortality.
Study context
- Population
- Injured patients at risk of large volume blood transfusion and the need for hemorrhage control procedures, 5 US trauma centers
- Comparison
- Early cold stored platelet transfusion vs standard care resuscitation
- Primary endpoint
- Feasibility; principal clinical outcome for efficacy and safety: 24-hour mortality
- Follow-up
- 24 hours
Methodological detailsphase 2, multicentre, open label
- Phase 2
- Multicentre
- Open label
Primary result
24-hour mortality
Difference
−4.3%
95% CI −12.8% to 3.5%
P = 0.26
By group
Cold stored platelets vs Standard care
difference −4.3% (95% CI −12.8% to 3.5%); P = 0.26
As reported in the abstract
Further findings
- No significant differences for any prespecified ancillary outcome
Safety
Arterial and/or venous thromboembolism and adverse events
- Rates did not differ across treatment groups
Original publication
Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial. Ann Surg. Published 6 May 2024. doi:10.
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