Pediatric anesthesia & critical care
Early Enteral Nutrition and Clinical Outcomes in Critically Ill Pediatric Populations: A Systematic Review and Meta-Analysis
Pooled result · Mortality, severity-adjusted analysisResult — go to the resultAdjusted odds ratio 0.36 95% CI 0.14–0.91Authors' conclusion
EEN was associated with beneficial outcomes.
Study context
- Population
- Critically ill children
- Participants
- 9,829 children · 18 studies
- Comparison
- Early enteral nutrition (EN) vs delayed EN
- Outcome
- Mortality (adjusted for illness severity)
Methodological detailsrandom-effects models, Grading of Recommendations Assessment, Development, and Evaluation (GRADE) assessment
- Random-effects models
- GRADE assessment
Pooled result
Mortality, severity-adjusted analysis
Adjusted odds ratio
0.36
95% CI 0.14–0.91
EEN vs DEN
aOR 0.36 (95% CI 0.14–0.91)
As reported in the abstract
Further pooled results
LOS, invasive respiratory support duration, nutrition adequacy, maximum pediatric logistic organ dysfunction score, infection (qualitative review)
- EEN associated with reduced LOS, length of invasive respiratory support, improved nutrition adequacy, reduced maximum pediatric logistic organ dysfunction score, and infection
Safety
- No harmful effects of EEN found after adjusting for confounding variables
Original publication
Early Enteral Nutrition and Clinical Outcomes in Critically Ill Pediatric Populations: A Systematic Review and Meta-Analysis. Crit Care Med. Published 17 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →