ICU sedation, delirium & recovery
Early mobilization for mechanical ventilation for sepsis or acute respiratory failure (EVER): a multicenter randomized controlled trial with 12-month outcomes
Authors' conclusion
In this multicenter randomized controlled trial of mechanically ventilated patients with sepsis or acute respiratory failure, a protocolized early mobilization program did not improve functional status at ICU discharge or at 12 months compared with usual care.
Study context
- Population
- Adults with sepsis or respiratory failure anticipated to require invasive ventilation for ≥ 48 h, five tertiary hospitals in South Korea (September 2020 to July 2024)
- Participants
- 169 adults
- Comparison
- Structured six-step early mobilization programme vs usual care
- Interventionn = 93
- Usual caren = 76reference
- Primary endpoint
- FSS-ICU
- Follow-up
- ICU discharge
Methodological detailsmulticentre, open-label, 1:1 randomisation
- Multicentre
- Open-label
- 1:1 randomisation
Primary result
As reported in the abstract
- Intervention vs Usual care: P = 0.44
- Intention-to-treat
Secondary outcomes
Time to start of mobilization
Accumulated mobilization time
Median
| Outcome | Intervention | Usual care | P value |
|---|---|---|---|
| Number of mobilization sessions | 11 | 4 | |
| FSS-ICU, patients achieving mobilization Step ≥ 4 (sit to stand or higher) vs matched usual care (subgroup) · ICU dischargeMatched comparison | P < 0.01 |
- FSS-ICU, patients achieving mobilization Step ≥ 4 (sit to stand or higher) vs matched usual care (subgroup): Step ≥ 4 mean 30.6
- FSS-ICU, patients achieving mobilization Step ≥ 4 (sit to stand or higher) vs matched usual care (subgroup): Matched usual care mean 23.3
Long-term outcomes (EQ-5D, SF-36 PCS/MCS, IES-R-K, MoCA-BLIND, PICS) · 12 months
- Improved similarly in both groups over 12 months without significant differences
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Early mobilization for mechanical ventilation for sepsis or acute respiratory failure (EVER): a multicenter randomized controlled trial with 12-month outcomes. Intensive Care Med. Published 26 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →