Neuroanesthesia & neurocritical care
Early Relative Hypotension Below Noninvasive Cerebral Oximetry-Derived Optimal Blood Pressure Thresholds in Aneurysmal Subarachnoid Hemorrhage: A Pilot Study
Main findingResult — go to the resultAdjusted odds ratio 1.02 95% CI 1.002–1.03Authors' conclusion
Defining individualized MAP Opt thresholds using noninvasive cerebral oximetry was feasible. Relative hypotension below oximetry-based MAP Opt in the EBI and pre-DCI phase (days~2-6) was associated with DCI and poor long-term functional outcome
Study context
- Population
- Aneurysmal subarachnoid hemorrhage (aSAH) patients with altered consciousness, single-centre Neuro-ICU, continuous noninvasive cerebral oximetry118 daily MAP Opt measurements
- Participants
- 35 patients
- Exposure
- Delayed cerebral ischemia (DCI) vs no DCI; %time below cerebral oximetry-derived MAP Opt range
- DCIn = 15
Methodological detailssingle-centre, Cerebral oximetry monitoring for median 4 days (IQR 3-4 d), beginning median hospital day 2 (1-3)
- Single-centre
- Cerebral oximetry monitoring for median 4 days (IQR 3-4 d), beginning median hospital day 2 (1-3)
Main finding
As reported in the abstract
Adjusted odds ratio
1.02
95% CI 1.002–1.03
P = 0.03
%time below MAP Opt range
aOR 1.02 (95% CI 1.002–1.03); P = 0.03
- Feasibility (118/128 epochs)
- 92.2%
Observational data: associations, not effects.
Further findings
Median MAP Opt (early phase)
P = 0.03
%time with MAP Obs below MAP Opt range (early phase)
P = 0.01
| Outcome | DCI | No DCI |
|---|---|---|
| MAP Opt trajectory (β-coefficient)mm Hg | +19 | +4 |
| p | p = 0.04 | p = 0.56 |
Incidence of DCI and poor 1-year outcome
- DCI
- 15 (42.9%)
- Poor 1-year outcome
- 20 (57.1%)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Early Relative Hypotension Below Noninvasive Cerebral Oximetry-Derived Optimal Blood Pressure Thresholds in Aneurysmal Subarachnoid Hemorrhage: A Pilot Study. Crit Care Med. Published 19 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →