Cardiac arrest & resuscitation
EEG-guided early cessation of sedation and targeted temperature management (TTM) in patients after cardiac arrest: a feasibility and safety study
Authors' conclusion
Early withdrawal of sedation is feasible and safe in patients with an early favourable EEG following cardiac arrest. The study was underpowered to detect possible differences in long-term neurological recovery.
Study context
- Population
- Adults in ICU with postanoxic encephalopathy after cardiac arrest and an early (<12 h) favourable EEG pattern
- Participants
- 40 adults
- Comparison
- Intervention vs Control
- Primary endpoint
- Duration of mechanical ventilation
Methodological detailsfeasibility and safety study
- Feasibility and safety study
Primary result
As reported in the abstract
P < 0.001
Secondary outcomes
ICU LOS
P = 0.001
| Outcome | Intervention | Control | P value |
|---|---|---|---|
| Total sedation time | — not stated in the abstract | median 27 h | P < 0.001 |
— not stated in the abstract
Neurological outcomes · 3 and 6 months
- No statistically significant differences at 3 or 6 months
Safety
- No increase in ICU complications in the intervention group
Original publication
EEG-guided early cessation of sedation and TTM in patients after cardiac arrest: a feasibility and safety study. Resuscitation. Published 17 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →