The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: a cluster randomised stepped-wedge trial
Authors' conclusion
This cluster randomised stepped-wedge trial showed that tailoring potential DDI alerts to the ICU setting significantly reduced the number of administered high-risk drug combinations.
Study context
- Population
- Patients aged ≥18 years admitted to the intensive care unit (ICU) with at least two drugs administered, nine ICUs in the Netherlands10,423 assessed
- Participants
- 9,887 patients
- Comparison
- ICU-tailored CDSS alerts for high-risk potential drug-drug interactions (DDIs) only vs control
- Interventionn = 5,534
- Controln = 4,353reference
- Primary endpoint
- Number of administered high-risk drug combinations per 1000 drug administrations per patient
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Decrease
12%
95% CI 5–18%
P = 0.0008
By group
Intervention
26.2
mean · SD 53.4
Control
35.6
mean · SD 65.0
Original publication
The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: a cluster randomised stepped-wedge trial. Lancet. Published 20 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →