Perioperative medicine & outcomes
Effect of continuing angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers on the day of surgery on myocardial injury after non-cardiac surgery: A retrospective cohort study
Main findingResult — go to the resultOdds ratio 1.17 95% CI 1.07–1.27Authors' conclusion
Withholding ACEI/ARB before surgery was associated with a reduced risk of intraoperative hypotension and postoperative myocardial injury, but it did not affect overall clinical outcomes in patients undergoing non-cardiac surgery.
Study context
- Population
- Patients on chronic angiotensin-converting enzyme inhibitor (ACEI)/ARB undergoing non-cardiac surgery, January 2012 to June 202211,373 per group matched
- Participants
- 42,432 patients
- Exposure
- Continuing vs withholding ACEI/ARB 24 h before surgery
- Continuedn = 11,377
- Withheldn = 31,055reference
- Outcome
- MINS
- Follow-up
- Within 7 days postoperatively
Methodological detailssingle-centre, propensity-score matched
- Single-centre
- Propensity-score matched
Main finding
As reported in the abstract
Odds ratio
1.17
95% CI 1.07–1.27
P < 0.001
Events by group
Continued vs Withheld
OR 1.17 (95% CI 1.07–1.27); P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Continued | Withheld | Estimate | P value |
|---|---|---|---|---|
| MINS, propensity-matched cohort · within 7 days postoperatively | 7.4% | — not stated in the abstract | ||
| Time-average weight of MAP <65 mmHg during surgeryMean | 0.11 | 0.09 | (95% CI 0.01–0.03) | P < 0.001 |
— not stated in the abstract
- MINS, propensity-matched cohort: 1:1 propensity score matching, 11,373 per group
Other clinical outcomes and mortality
- No significant difference in other clinical outcomes and mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of continuing angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers on the day of surgery on myocardial injury after non-cardiac surgery: A retrospective cohort study. J Clin Anesth. Published 8 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →