Effect of Local Anesthetic Solution at Different Temperatures for Epidural Labor Analgesia on Intrapartum Fever: A Randomized Clinical Trial
Primary result · Intrapartum feverResult — go to the resultRelative risk 0.5 95% CI 0.298–0.840Authors' conclusion
Although we found a 50% reduction in the incidence of temperature rise using warmed (37°C) local anesthetics for epidural labor analgesia, this did not reach our preset threshold of 60% reduction.
Study context
- Population
- Nulliparous parturients, 18–35 years, ASA II, term singleton pregnancy, receiving epidural labor analgesia
- Participants
- 220 participants
- Comparison
- Epidural labour analgesia solution at 37°C vs 22°C
- Warmedn = 110
- Room-temperaturen = 110reference
- Primary endpoint
- Intrapartum fever incidence (tympanic temperature ≥38°C); also maximum temperature and shivering
- Follow-up
- Epidural initiation to delivery
Methodological detailsdouble-blind
- Double-blind
Primary result
Intrapartum fever
Relative risk
0.5
95% CI 0.298–0.840
P = 0.007
Events by treatment group
Warmed vs Room-temperature
RR 0.5 (95% CI 0.298–0.840); P = 0.007
As reported in the abstract
Secondary outcomes
| Outcome | Warmed | Room-temperature | Median difference (°C) (95% CI) | P value | |
|---|---|---|---|---|---|
| Maximum body temperature | median 37.4 (IQR 37.2–37.7) °C | median 37.6 (IQR 37.3–38.0) °C | −0.2 (−0.3 to −0.1) | P = 0.006 | |
| −0.4−0.200.2Difference, °C (linear scale) |
| Outcome | P value |
|---|---|
| ShiveringNot different between groups | P = 0.418 |
Block characteristics, LA consumption, labor duration, neonatal outcomes
- No statistically significant differences between groups
Safety
Maternal adverse events
- No statistically significant differences between groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of Local Anesthetic Solution at Different Temperatures for Epidural Labor Analgesia on Intrapartum Fever: A Randomized Clinical Trial. Anesth Analg. Published 6 April 2026. doi:10.
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