Pediatric anesthesia & critical care
Effect of neuromuscular block on surgical conditions during laparoscopic surgery in neonates and small infants: A randomised controlled trial
Authors' conclusion
The depth of NMB was not associated with superior surgical conditions during laparoscopic surgery, but it was associated with a reduction in adverse events during induction and maintenance of anaesthesia in neonates and small infants.
Study context
- Population
- ASA I–II neonates and small infants up to 60 weeks postmenstrual age scheduled for elective laparoscopic Ladd's procedure
- Participants
- 102 neonates
- Comparison
- No neuromuscular block (NMB) vs shallow NMB vs moderate NMB
- Primary endpoint
- Quality of surgical conditions (Leiden-Surgical Rating Scale, L-SRS) rated by a blinded surgeon
Methodological detailssingle-centre, blinded surgeon assessment, Single-centre Children's Hospital, November 2021 to December 2022
- Single-centre
- Blinded surgeon assessment
- Single-centre Children's Hospital, November 2021 to December 2022
Primary result
As reported in the abstract
L-SRS score 4 or 5 · all assessment times
- Percentage of Leiden-Surgical Rating Scale (L-SRS) scores of 4 or 5 similar among the three groups (P > 0.05 for each time interval)
- Distribution of L-SRS scores similar among the three groups
- No significant differences in operating condition scores between groups at any time interval (P > 0.05 for each time interval)
Secondary outcomes
Clinically unacceptable intubation conditions — Shallow NMB vs No NMB
adjusted P = 0.012
| Outcome | P value |
|---|---|
| Clinically unacceptable intubation conditionsModerate NMB vs No NMB | adjusted P = 0.003 |
Safety
Adverse events during anaesthesia induction — Shallow NMB vs No NMB
adjusted P = 0.012
| Outcome | P value |
|---|---|
| Adverse events during anaesthesia inductionModerate NMB vs No NMB | adjusted P = 0.003 |
Adverse events in the PACU
- No statistically significant difference among the three groups
- P = 0.103
Original publication
Effect of neuromuscular block on surgical conditions during laparoscopic surgery in neonates and small infants: A randomised controlled trial. Eur J Anaesthesiol. Published 23 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →