Perioperative medicine & outcomes
Effect of perioperative dexmedetomidine on acute kidney injury after partial nephrectomy: a single-centre, randomised, double-blind, placebo-controlled trial
Primary result · AKIResult — go to the resultRelative risk 0.97 95% CI 0.63–1.49Authors' conclusion
Perioperative dexmedetomidine administration did not reduce postoperative AKI after partial nephrectomy.
Study context
- Population
- Adults undergoing partial nephrectomy, tertiary care hospital in Beijing, China288 in modified ITT analysis
- Participants
- 290 adults
- Comparison
- Perioperative dexmedetomidine vs saline
- Dexmedetomidinen = 144
- Salinen = 144reference
- Primary endpoint
- Incidence of acute kidney injury (AKI) (KDIGO creatinine criteria)
Methodological detailssingle-centre, double-blind, placebo-controlled
- Single-centre
- Double-blind
- Placebo-controlled
Primary result
AKI
Relative risk
0.97
95% CI 0.63–1.49
P = 0.888
Events by treatment group
Dexmedetomidine vs Saline
RR 0.97 (95% CI 0.63–1.49); P = 0.888
As reported in the abstract
Secondary outcomes
Postoperative serum cystatin C, serum creatinine and eGFR in postoperative 6 months
- Not different between groups
Safety
Safety outcomes
- Incidence similar in each group
Original publication
Effect of perioperative dexmedetomidine on acute kidney injury after partial nephrectomy: a single-centre, randomised, double-blind, placebo-controlled trial. Br J Anaesth. Published 10 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →