Perioperative medicine & outcomes
Effect of S-Ketamine on Postoperative Delirium in Elderly Patients Undergoing Arthroplasty: A Randomized Controlled Trial
Primary resultResult — go to the resultAdjusted odds ratio 0.29 95% CI 0.14–0.63Authors' conclusion
S-ketamine can reduce risk of POD in elderly patients undergoing total hip or knee arthroplasty under neuraxial anesthesia.
Study context
- Population
- Elderly patients undergoing total hip or knee arthroplasty under neuraxial anesthesia, high-volume arthroplasty referral center
- Participants
- 372 patients
- Comparison
- S-ketamine vs normal saline placebo under neuraxial anaesthesia
- S-ketaminen = 186
- Placebon = 186reference
- Primary endpoint
- Risk of POD
- Follow-up
- Within 3 days after surgery
Methodological detailsplacebo-controlled, single-centre, Enrolled November 2023 to October 2024; in-person follow-up from admission to 3 days after surgery
- Placebo-controlled
- Single-centre
- Enrolled November 2023 to October 2024; in-person follow-up from admission to 3 days after surgery
Primary result
As reported in the abstract
Adjusted odds ratio
0.29
95% CI 0.14–0.63
P = 0.002
Events by treatment group
S-ketamine vs Placebo
aOR 0.29 (95% CI 0.14–0.63); P = 0.002
Secondary outcomes
Pain during exercise and physical therapy; rescue analgesia use · postoperative delirium (POD) 1
- Significantly less pain during exercise and physical therapy and lower incidence of rescue analgesia use with S-ketamine vs placebo
Safety
- Incidence of hallucinations, dizziness and nightmares higher with S-ketamine vs placebo
- Other complications low in both groups, no statistically significant differences
Original publication
Effect of S-Ketamine on Postoperative Delirium in Elderly Patients Undergoing Arthroplasty: A Randomized Controlled Trial. Anesthesiology. Published 14 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →