Effectiveness of a Pharmacist-Led Intervention to Reduce Acid Suppression Therapy for Stress Ulcer Prophylaxis in ICUs in China: A Multicenter, Stepped-Wedge, Cluster-Randomized Controlled Trial
Primary result · Patients receiving SUPResult — go to the resultOdds ratio 0.81 95% CI 0.68–0.96Authors' conclusion
The pharmacist-led intervention reduced the proportion of patients receiving SUP in the ICUs, without significantly affecting the proportion of patients with overt gastrointestinal bleeding.
Study context
- Population
- Adults (≥18 years) newly admitted to 26 ICUs in China, October 2022 to March 2023
- Participants
- 2,199 adults · 26 ICUs
- Comparison
- Pharmacist-led intervention vs usual care
- Primary endpoint
- Proportion of patients receiving stress ulcer prophylaxis (SUP) and proportion with overt gastrointestinal bleeding
Methodological detailspragmatic, multicentre, stepped-wedge
- Pragmatic
- Multicentre
- Stepped-wedge
Primary result
Patients receiving SUP
Odds ratio
0.81
95% CI 0.68–0.96
P = 0.017
By group
Intervention vs Control
OR 0.81 (95% CI 0.68–0.96); P = 0.017
As reported in the abstract
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effectiveness of a Pharmacist-Led Intervention to Reduce Acid Suppression Therapy for Stress Ulcer Prophylaxis in ICUs in China: A Multicenter, Stepped-Wedge, Cluster-Randomized Controlled Trial. Crit Care Med. Published 30 January 2025. doi:10.
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