Neuroanesthesia & neurocritical care
Effects of an Early Intensive Blood Pressure–lowering Strategy Using Remifentanil and Dexmedetomidine in Patients with Spontaneous Intracerebral Hemorrhage: A Multicenter, Prospective, Superiority, Randomized Controlled Trial
Primary resultResult — go to the resultDifference 23.2% 95% CI 12.4–34.1%Authors' conclusion
Among intracerebral hemorrhage patients with a SBP 150 mmHg or greater, a preset protocol using a remifentanil and dexmedetomidine-based standard guideline management significantly increased the SBP control rate at 1 h posttreatment compared with the standard guideline-based management.
Study context
- Population
- Patients with spontaneous intracerebral hemorrhage and systolic blood pressure (SBP) 150 mmHg or greater
- Participants
- 338 patients
- Comparison
- Intervention vs Control
- Interventionn = 167
- Controln = 171reference
- Primary endpoint
- SBP control rate (less than 140 mmHg)
- Follow-up
- 1 h posttreatment initiation
Methodological detailsmulticentre, prospective, single-blinded, superiority
- Multicentre
- Prospective
- Single-blinded
- Superiority
Primary result
As reported in the abstract
Difference
23.2%
95% CI 12.4–34.1%
P < 0.001
Events by treatment group
Intervention vs Control
difference 23.2% (95% CI 12.4–34.1%); P < 0.001
Secondary outcomes
Agitation and sedation
- Intervention effectively reduced agitation while achieving lighter sedation
Clinical outcomes
- No improvement in clinical outcomes
Safety
Bradycardia and respiratory depression
- Higher incidence in the intervention group
Original publication
Effects of an Early Intensive Blood Pressure–lowering Strategy Using Remifentanil and Dexmedetomidine in Patients with Spontaneous Intracerebral Hemorrhage: A Multicenter, Prospective, Superiority, Randomized Controlled Trial. Anesthesiology. Published 27 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →