Perioperative medicine & outcomes
Effects of an open lung extubation strategy compared with a conventional extubation strategy on postoperative pulmonary complications after general anesthesia: a single-centre pilot randomized controlled trial
Authors' conclusion
In this single-centre pilot trial, we observed excellent feasibility.
Study context
- Population
- Adults at moderate to high risk of postoperative pulmonary complications (PPCs) scheduled for elective surgery
- Participants
- 34 vs 35
- Comparison
- Open lung extubation strategy vs conventional extubation strategy
- Open lung extubationn = 34
- Conventional extubationn = 35reference
- Primary endpoint
- Global protocol adherence (feasibility); PPCs (primary exploratory efficacy outcome)
Methodological detailspilot, single-centre, double-blinded
- Pilot
- Single-centre
- Double-blinded
Primary result
As reported in the abstract
Global protocol adherence
Global protocol adherence
96%
95% CI 88 to 99
Further findings
Events
| Outcome | Conventional extubation | Open lung extubation |
|---|---|---|
| PPCs (primary exploratory efficacy outcome) | 2 | 6 |
- PPCs (primary exploratory efficacy outcome) — Total PPCs
- 8
Postoperative supplemental oxygen and lung aeration
- Less postoperative supplemental oxygen and better lung aeration in the open lung extubation group
Original publication
Effects of an open lung extubation strategy compared with a conventional extubation strategy on postoperative pulmonary complications after general anesthesia: a single-centre pilot randomized controlled trial. Can J Anaesth. Published 27 July 2023. doi:10.
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