Effects of S-ketamine added to patient-controlled analgesia on early postoperative pain and recovery in patients undergoing thoracoscopic lung surgery: A randomized double-blinded controlled trial
Primary result · Postoperative moderate-to-severe painResult — go to the resultAbsolute difference 27.9% 95% CI 11.7%–42.1%Authors' conclusion
Addition of S-ketamine to IV-PCA hydromorphone significantly reduced the incidence of postoperative moderate-to-severe pain and improved the QoR in patients undergoing thoracoscopic lung surgery.
Study context
- Population
- Patients undergoing thoracoscopic lung surgery, tertiary university hospital220 analysed
- Participants
- 242 patients
- Comparison
- Intravenous patient-controlled analgesia (IV-PCA) hydromorphone plus S-ketamine vs hydromorphone alone
- Primary endpoint
- Proportion with moderate-to-severe pain (NRS ≥4 when coughing)
- Follow-up
- Within 2 days after surgery
Methodological detailssingle-centre, prospective, double-blinded
- Single-centre
- Prospective
- Double-blinded
Primary result
Postoperative moderate-to-severe pain
Absolute difference
27.9%
95% CI 11.7%–42.1%
P < 0.001
Combined S-ketamine vs Hydromorphone
absolute difference 27.9% (95% CI 11.7%–42.1%); P < 0.001
As reported in the abstract
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| NRS pain scores at rest and when coughing · POD1Lower with S-ketamine; 1 at rest and 1 when coughing | median difference 1 | P < 0.001 |
| NRS pain scores at rest and when coughing · POD2Lower with S-ketamine; 1 at rest and 1 when coughing | median difference 1 | P < 0.001 |
| QoR-15 score · POD1Higher with S-ketamine | mean difference 6 | P < 0.001 |
| QoR-15 score · POD2Higher with S-ketamine | mean difference 6 | P < 0.001 |
Safety
Sedation
- Higher S-ketamine dose associated with deeper sedation
Other safety outcomes
- No differences detected
Original publication
Effects of S-ketamine added to patient-controlled analgesia on early postoperative pain and recovery in patients undergoing thoracoscopic lung surgery: A randomized double-blinded controlled trial. J Clin Anesth. Published 7 November 2023. doi:10.
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