ICU sedation, delirium & recovery
Efficacy and Safety of Remimazolam Tosylate versus Propofol for Sedation of Postoperative Mechanically Ventilated Patients in Intensive Care Units: A Multicenter, Randomized, Single-blind, Noninferiority, Phase 3 Trial
Primary resultResult — go to the resultDifference 1.9% 95% CI −3.3 to 7.8%Authors' conclusion
Remimazolam tosylate demonstrated noninferior efficacy and good tolerability compared with propofol for short-term sedation in postoperative mechanically ventilated intensive care unit patients.
Study context
- Population
- Mechanically ventilated (99.1% postoperative) ICU patients requiring sedation for 6 h or longer, target Richmond Agitation-Sedation Scale (RASS) −2 to +1
- Participants
- 211 participants
- Comparison
- Remimazolam tosylate vs propofol for sedation
- Remimazolam tosylaten = 106
- Propofoln = 105reference
- Primary endpoint
- Sedation success: maintaining target sedation range for 70% or more of drug administration time without rescue sedation
Methodological detailsmulticentre, single-blind, actively controlled, noninferiority, phase 3, Maximum treatment duration 24 h, March 12, 2024 to September 24, 2024
- Multicentre
- Single-blind
- Actively controlled
- Noninferiority
- Phase 3
- Maximum treatment duration 24 h
- March 12, 2024 to September 24, 2024
Primary result
As reported in the abstract
Difference
1.9%
95% CI −3.3 to 7.8%
By group
Remimazolam tosylate vs Propofol
difference 1.9% (95% CI −3.3 to 7.8%)
Further findings
Rescue sedation
Treatment duration
Total dose
Mean
| Outcome | Remimazolam tosylate | Propofol |
|---|---|---|
| Percentage of time in RASS target range | 95.1% (SD 13.8%) | 95.0% (SD 12.9%) |
| Additional doses required | 0.03 (SD 0.17) | 0.18 (SD 0.77) |
- Terminal half-life of remimazolam tosylate
- 1.97 · mean · SD 1.62 · h
Safety
Adverse events
Adverse events
- All mild-moderate, except one severe with propofol
Original publication
Efficacy and Safety of Remimazolam Tosylate versus Propofol for Sedation of Postoperative Mechanically Ventilated Patients in Intensive Care Units: A Multicenter, Randomized, Single-blind, Noninferiority, Phase 3 Trial. Anesthesiology. Published 19 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →