Electronic health record interventions to reduce postoperative pregabalin prescribing: a quality improvement initiative
Authors' conclusion
We did not identify a significant association of EHR interventions with pregabalin prescribing. Nevertheless, a continued downtrend in pregabalin prescribing was not associated with worsening acute pain.
Study context
- Population
- Patients under the acute pain service (APS) at a multi-site academic health sciences network
- Participants
- 10,667 participants
- Exposure
- Two electronic health record (EHR) interventions vs preintervention
- Preinterventionn = 5,559reference
- Postintervention 1n = 2,271
- Postintervention 2n = 2,837
- Outcome
- Proportion of patients receiving pregabalin during their APS admission
Methodological detailsretrospective observational cohort and quasi-experimental interrupted time series, segmented regression, multi-site
- Retrospective observational cohort and quasi-experimental interrupted time series
- Segmented regression
- Multi-site
Main finding
As reported in the abstract
Postintervention 1 vs Preintervention: P = 0.76 · Postintervention 2 vs Preintervention: P = 0.11
- Preintervention trend (per week)
- −0.2%
Observational data: associations, not effects.
Safety
Highest POD 1 pain score (balancing measure)
- No changes in pain intensity scores despite decreased pregabalin use over time
Original publication
Electronic health record interventions to reduce postoperative pregabalin prescribing: a quality improvement initiative. Can J Anaesth. Published 29 September 2025. doi:10.
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