Etomidate as an induction agent for endotracheal intubation in critically ill patients: A meta-analysis of randomized trials
Pooled resultResult — go to the resultRelative risk 1.16 95% CI 1.01–1.33Authors' conclusion
This meta-analysis found a high probability that etomidate increases mortality when used as an induction agent in critically ill patients with a number needed to harm of 31.
Study context
- Population
- Critically ill adults undergoing endotracheal intubation
- Participants
- 2,704 adults · 11 RCTs
- Comparison
- Etomidate vs other induction agents
- Etomidaten = 1,359
- Other induction agentsn = 1,345reference
- Outcome
- Mortality at the main timepoint defined by the study
Methodological detailsfixed-effects meta-analysis
- Fixed-effects meta-analysis
Pooled result
As reported in the abstract
Relative risk
1.16
95% CI 1.01–1.33
P = 0.03
Events by group
Etomidate vs Other induction agents
RR 1.16 (95% CI 1.01–1.33); P = 0.03
- Probability of any increase in mortality
- 98.1%
- Probability of a 1% increase in mortality (NNH ≤100)
- 92.1%
Original publication
Etomidate as an induction agent for endotracheal intubation in critically ill patients: A meta-analysis of randomized trials. J Crit Care. Published 29 April 2023. doi:10.
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