Evaluating the Impact of Glucagon-Like Peptide-1 Receptor Agonist Receptor Agonists on Postoperative Pain Management in Patients Undergoing Cancer Surgery: A Retrospective Study
Authors' conclusion
GLP-1RA use was not associated with clinically meaningful reductions in perioperative opioid use or pain scores.
Study context
- Population
- Adults undergoing elective oncological surgery under GA at an academic center
- Participants
- 17,027 adults · 486 matched pairs
- Exposure
- GLP-1RA users vs non-users
- GLP-1RAn = 486
- non-GLP-1RAn = 486reference
- Outcome
- Perioperative opioid consumption (OME) and pain intensity
Methodological detailsmatched cohort, single academic centre
- Matched cohort
- Single academic centre
Main finding
As reported in the abstract
Intraoperative OME
P = 0.55
Observational data: associations, not effects.
Further findings
| Outcome | Difference (95% CI) | P value | |
|---|---|---|---|
| OME in PACU | −0.94 (−2.49 to 0.61) | P = 0.23 | |
| OME on POD0 | −0.29 (−1.21 to 0.62) | P = 0.52 | |
| OME on POD1 | −1.18 (−3.36 to 1.01) | P = 0.29 | |
| OME on POD2Significant reduction with GLP-1RA | −1.98 (−3.82 to −0.13) | P = 0.04 | |
| OME on POD3Significant reduction with GLP-1RA | −1.94 (−3.57 to −0.31) | P = 0.02 | |
| −4−202Difference (linear scale) |
Pain scores
- No statistically significant differences between groups
Cohort × postoperative time interaction (linear mixed-effects model)
- Interaction not significant for oral morphine equivalents (OME)
- P = 0.1
- Interaction not significant for pain scores
- P = 0.86
Original publication
Evaluating the Impact of Glucagon-Like Peptide-1 Receptor Agonist Receptor Agonists on Postoperative Pain Management in Patients Undergoing Cancer Surgery: A Retrospective Study. Anesth Analg. Published 12 February 2026. doi:10.
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