Paediatric anaesthesia & critical care
Evaluation of a Rapid Immunoassay for Molecular Subphenotype Classification in Pediatric Acute Cardiorespiratory Failure
Authors' conclusion
A parsimonious, rapid immunoassay-based classifier can approximate LCA-derived molecular subphenotypes while preserving their prognostic and predictive significance, with the potential to inform future subphenotype-based precision trials.
Study context
- Population
- Critically ill children with acute cardiorespiratory failure and hyperglycemia in multicentre PICUs (2012–2016)
- Participants
- 269 children
- Exposure
- Rapid immunoassay vs conventional multiplex assay for latent class analysis (LCA)-derived subphenotype classification
- Outcome
- Discrimination for LCA-derived subphenotypes (AUROC)
Methodological detailsmulticentre, bootstrapping internal validation
- Multicentre
- Bootstrapping internal validation
Main finding
As reported in the abstract
| Group | Value | Accuracy (threshold ≥ 0.5) | Matched LCA-derived classifications |
|---|---|---|---|
| Parsimonious classifier | AUROC 0.90 (95% CI 0.85–0.95) | ||
| De novo classifier | AUROC 0.90 (95% CI 0.86–0.95) | 89.6% | 241 of 269 |
Value
Parsimonious classifierAUROC 0.90 (95% CI 0.85–0.95)
De novo classifierAUROC 0.90 (95% CI 0.86–0.95)
Accuracy (threshold ≥ 0.5)
Parsimonious classifier— not stated in the abstract
De novo classifier89.6%
Matched LCA-derived classifications
Parsimonious classifier— not stated in the abstract
De novo classifier241 of 269
Observational data: associations, not effects.
Further findings
Mortality by rapid immunoassay-based subphenotype
P = 0.009
Differential response to intensive insulin management by subphenotype
- Differential response to intensive insulin management
- Interaction p = 0.024
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Evaluation of a Rapid Immunoassay for Molecular Subphenotype Classification in Pediatric Acute Cardiorespiratory Failure. Crit Care Med. Published 7 September 2026. doi:10.
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