Perioperative medicine & outcomes
Examining cefazolin utilization and perioperative anaphylaxis in patients with and without a penicillin allergy label: A cross-sectional study
Authors' conclusion
The prevalence of cefazolin POA does not exhibit significant differences between patients with and without PALs, and notably, the incidence remains remarkably low.
Study context
- Population
- Surgical encounters (inpatient and outpatient, various specialties) receiving perioperative cefazolin, large US healthcare system, Baltimore-D.C. region, July 2017 to July 2020
- Participants
- 112,817 encounters
- Exposure
- Penicillin allergy label vs no penicillin allergy label (PAL)
- PALn = 4,876
- Outcome
- Cefazolin perioperative anaphylaxis (POA) in patients with and without PALs
Main finding
As reported in the abstract
Cefazolin POA
PAL
1
events
P = 0.437
- Possible cefazolin hypersensitivity reaction (HSRs)
- 1421 (1.3%)
- Perioperative anaphylaxis (POA) among possible HSRs
- 22 (1.5%)
- POA prevalence
- 0.02%
- POA linked to cefazolin
- 13 (59.1%)
- POA attributed to other drugs
- 9 (40.9%)
Observational data: associations, not effects.
Secondary outcomes
Perioperative cefazolin use in patients with PALs · 2017 to 2020
- Steadily increased, specifically in academic settings
- 2.6% to 6.0%
Original publication
Examining cefazolin utilization and perioperative anaphylaxis in patients with and without a penicillin allergy label: A cross-sectional study. J Clin Anesth. Published 18 January 2024. doi:10.
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