Examining the relationship between autism spectrum disorder in children whose mother had labour epidural analgesia for their birth: A retrospective cohort study
Main finding · ASD in the childrenResult — go to the resultAdjusted hazard ratio 1.13 95% CI 0.96–1.34Authors' conclusion
In our population, after adjusting for confounders, epidural analgesia is not independently associated with autism spectrum disorder in the children.
Study context
- Population
- Vaginal deliveries 2005–2017 at Soroka University Medical Center, Israel, and their offspring followed for autism spectrum disorder (ASD)labouring patients and offspring
- Participants
- 139,981 deliveries
- Exposure
- Labour epidural analgesia vs no labour epidural analgesia
- Epiduraln = 33,315
- Outcome
- Incidence of ASD in the children (hospital and community-based diagnoses)
Methodological detailssingle-centre, Cox proportional hazards model
- Single-centre
- Cox proportional hazards model
Main finding
ASD in the children
Adjusted hazard ratio
1.13
95% CI 0.96–1.34
P = 0.152
Epidural vs No epidural
aHR 1.13 (95% CI 0.96–1.34); P = 0.152
As reported in the abstract
Observational data: associations, not effects.
Further findings
High-risk pregnancy (DM, hypertensive disorders, intrauterine growth restriction, oligohydramnios)
- Epidural analgesia more common among high-risk pregnancy groups
- P < 0.001
Original publication
Examining the relationship between autism spectrum disorder in children whose mother had labour epidural analgesia for their birth: A retrospective cohort study. Eur J Anaesthesiol. Published 11 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →