Exploration of the optimal programmed intermittent epidural bolus volume with the dural puncture epidural technique for labour analgesia: a biased-coin up-and-down sequential allocation study
Authors' conclusion
The estimated PIEB EV90 for ropivacaine 0.1% and sufentanil 0.3 μg·mL-1 approached 9 mL when DPE was combined with a fixed 40-min interval.
Study context
- Population
- Nulliparous women requiring epidural labour analgesia
- Participants
- 40 women
- Outcome
- Effective analgesia: no need for patient-controlled or manual boluses within 6 hr after analgesia initiation or until complete cervical dilation, whichever first
Methodological detailsdose-finding
- Dose-finding
Main finding
As reported in the abstract
Programmed intermittent epidural bolus (PIEB) EV90
EV90, truncated Dixon and Mood method
9.2 mL
95% CI 8.5 to 9.9
EV90, isotonic regression
8.8 mL
95% CI 8.6 to 9.8
Safety
- Motor block
- 0
- Hypotension without need for vasopressors
- 2
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Exploration of the optimal programmed intermittent epidural bolus volume with the dural puncture epidural technique for labour analgesia: a biased-coin up-and-down sequential allocation study. Can J Anaesth. Published 21 October 2024. doi:10.
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