Perioperative medicine & outcomes
Exploratory randomised trial of tranexamic acid to decrease postoperative delirium in adults undergoing lumbar fusion—a trial stopped early
Primary result · Delirium incidenceResult — go to the resultEffect size −0.258 95% CI −0.744 to 0.229- stopped early
Study context
- Population
- Adults undergoing elective posterior lumbar fusion65 had delirium assessments
- Participants
- 43 vs 40
- Comparison
- Intraoperative i.v. Tranexamic acid (TXA) vs placebo
- TXAn = 43
- Placebon = 40reference
- Primary endpoint
- Postoperative delirium incidence (twice daily delirium assessments)
Methodological detailsexploratory, placebo-controlled, added to an ongoing trial of TXA on blood loss
- Exploratory
- Placebo-controlled
- Added to an ongoing trial of TXA on blood loss
Primary result
Delirium incidence
Effect size
−0.258
95% CI −0.744 to 0.229
P = 0.408
Events by treatment group
As reported in the abstract
Further findings
Postoperative blood loss · ∼38% less with TXA
P = 0.013
Total blood loss · did not differ
P = 0.472
Original publication
Exploratory randomised trial of tranexamic acid to decrease postoperative delirium in adults undergoing lumbar fusion—a trial stopped early. BJA Open. Published 14 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →