External validation and comparative performance of the SLANT score for neuroprognostication in out-of-hospital cardiac arrest survivors undergoing targeted temperature management: insights from an Asian cohort
Authors' conclusion
The SLANT showed high PPV for predicting poor neurological outcomes at discharge in patients with OHCA undergoing TTM across a multicenter Asian cohort.
Study context
- Population
- Adults resuscitated from out-of-hospital cardiac arrest (OHCA) undergoing TTM, Asian cohort, 2016–2023
- Participants
- 448 adults
- Outcome
- Poor neurological outcome
- Follow-up
- Hospital discharge
Methodological detailsexternal validation of a prognostic score, multicentre
- External validation of a prognostic score
- Multicentre
Main finding
As reported in the abstract
Prediction of poor neurological outcome at discharge
| Group | AUC | Specificity (cutoff ≥ 6.5) | PPV (cutoff ≥ 6.5) | Specificity (cutoff 8.5) | PPV (cutoff 8.5) |
|---|---|---|---|---|---|
| SLANT | 0.797 (95% CI 0.746-0.849) | 53.5% | 86.9% | 66.7% | 89.6% |
SLANT
AUC0.797 (95% CI 0.746-0.849)
Specificity (cutoff ≥ 6.5)53.5%
PPV (cutoff ≥ 6.5)86.9%
Specificity (cutoff 8.5)66.7%
PPV (cutoff 8.5)89.6%
- Poor neurological outcome at discharge
- 77.9%
Observational data: associations, not effects.
Original publication
External validation and comparative performance of the SLANT score for neuroprognostication in out-of-hospital cardiac arrest survivors undergoing targeted temperature management: insights from an Asian cohort. J Intensive Care. Published 14 February 2025. doi:10.
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