Cardiac arrest & resuscitation
Extracorporeal Membrane Oxygenation for Cardiac Arrest: Does Age Matter?*
Authors' conclusion
We found that the odds of hospital survival for patients with CA treated with ECPR diminishes with increasing age, with significantly decreased odds of survival after age 65, despite controlling for illness severity and comorbidities.
Study context
- Population
- Adults ≥18 yr who underwent extracorporeal cardiopulmonary resuscitation (ECPR) for cardiac arrest, December 1, 2016 to October 31, 2020median age 57 yr (IQR 46–66)
- Participants
- 5,120 adults
- Exposure
- Age groups 50-64, 65-74 and > 75 vs 18-49 yr
- Outcome
- aOR of death after ECPR (hospital survival) by age group
Methodological detailsinternational registry (Extracorporeal Life Support Organization)
- International registry (Extracorporeal Life Support Organization)
Main finding
As reported in the abstract
Hospital survival by age group, vs 18-49
Each group vs 18-49AOR of survival (95% CI)
65-74
0.68(0.57–0.81)
>75
0.54(0.41–0.69)
50-64
0.91(0.79–1.05)
Observational data: associations, not effects.
Further findings
| Outcome | OR of survival (95% CI) | |
|---|---|---|
| Hospital survival, alternative age categories (sensitivity analysis), vs 18-6465-69 vs 18-64 · sensitivity analysis | 0.71 (0.59–0.86) | |
| Hospital survival, alternative age categories (sensitivity analysis), vs 18-6470-74 vs 18-64 · sensitivity analysis | 0.84 (0.67–1.04) | |
| Hospital survival, alternative age categories (sensitivity analysis), vs 18-64≥ 75 vs 18-64 · sensitivity analysis | 0.64 (0.50–0.81) | |
| 0.512OR of survival (log scale) |
Hospital survival, alternative age categories (sensitivity analysis), vs 18-64
- Decreased odds of survival for age ≥65 vs <65
Original publication
Extracorporeal Membrane Oxygenation for Cardiac Arrest: Does Age Matter?*. Crit Care Med. Published 2 October 2023. doi:10.
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