Factors associated with prolonged use of newly prescribed gabapentinoids in older adults undergoing colorectal surgery
Authors' conclusion
Factors associated with prolonged gabapentinoid use after colorectal surgery in the older adult population include initial prescription of a gabapentinoid without opioids, prolonged opioid use beyond discharge, and discharge to home with health services.
Study context
- Population
- Gabapentinoid-naïve Medicare patients ≥ 66 years undergoing colorectal surgery, October 2015–June 2018, newly prescribed a gabapentinoidnew gabapentinoid prescription
- Participants
- 979 patients
- Exposure
- Factors associated with prolonged gabapentinoid use
- Outcome
- Prolonged gabapentinoid use (prescription refills > 90 days after discharge)
Methodological details20% representative Medicare sample
- 20% representative Medicare sample
Main finding
As reported in the abstract
Prolonged gabapentinoid use (refills > 90 days after discharge)
Odds ratio (CI)P value
Concurrent peri-discharge opioid usereduced likelihood
0.48(0.34–0.66)
P < 0.0001Opioid use beyond 90 daysin patients with both opioid and gabapentinoid prescriptions at discharge
3.45(2.43–4.89)
P < 0.0001Patients discharged home with home health servicesincreased likelihood
1.53(1.08–2.17)
P = 0.047- Prolonged gabapentinoid use
- 22%
Observational data: associations, not effects.
Original publication
Factors associated with prolonged use of newly prescribed gabapentinoids in older adults undergoing colorectal surgery. Perioper Med (Lond). Published 2 July 2026. doi:10.
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