ICU sedation, delirium & recovery
Factors Influencing Quality of Life After Intensive Care: A Systematic Review and Meta-Analysis
Authors' conclusion
Most pre-ICU and intra-ICU factors demonstrated strong associations with post-ICU QOL. The QOL in post-ICU patients remains at a moderate level, with the PCS score indicating greater impairment than the MCS score.
Study context
- Population
- Post-ICU patients
- Participants
- 17,298 patients · 65 studies
- Outcome
- Factors influencing QOL and QOL levels after intensive care
Methodological details8 databases searched from inception to October 15, 2024, Two independent reviewers extracted data
- 8 databases searched from inception to October 15, 2024
- Two independent reviewers extracted data
Pooled result
As reported in the abstract
Factors associated with post-ICU QOL
- Advanced age (per 1-yr increase), β
- −0.045 (95% CI −0.057 to −0.033)
- Female gender, OR
- 1.104 (95% CI 1.035-1.177)
- ICU LOS (per 1-d increase), β
- −0.012 (95% CI −0.019 to −0.005)
- Length of mechanical ventilation (per 1-d increase), β
- −0.005 (95% CI −0.009 to −0.001)
- Hospital LOS (per 1-d increase), β
- −0.107 (95% CI −0.161 to −0.054)
Further pooled results
Pooled quality of life (QOL) levels
- Pooled overall QOL score
- 58.835 (95% CI 52.935-64.735)
- Pooled physical component summary (PCS) score
- 49.517 (95% CI 45.781-53.253)
- Pooled mental component summary (MCS) score
- 53.509 (95% CI 50.301-56.718)
- Pooled overall QOL index
- 0.750 (95% CI 0.713-0.787)
Original publication
Factors Influencing Quality of Life After Intensive Care: A Systematic Review and Meta-Analysis. Crit Care Med. Published 15 July 2025. doi:10.
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