Pediatric anesthesia & critical care
Fifth Centile Versus 50th Centile Mean Blood Pressure Targets in Pediatric Septic Shock: A Randomized Controlled Trial
Primary resultResult — go to the resultRisk difference 6.3 95% CI −6.9 to 19.2Authors' conclusion
Targeting a lower MBP (5th vs. 50th centile) in septic shock showed no significant difference in 28-day mortality.
Study context
- Population
- Children 1 month to 16 years with fluid-unresponsive septic shock requiring vasopressors, tertiary PICU, India, April 2021–March 2024
- Participants
- 144 children
- Comparison
- Mean blood pressure (MBP) target 5th vs 50th centile for vasoactive titration
- 5th centilen = 71
- 50th centilen = 73reference
- Primary endpoint
- All-cause mortality
- Follow-up
- 28 days
Methodological detailssingle-centre, open-label, noninferiority
- Single-centre
- Open-label
- Noninferiority
Primary result
As reported in the abstract
Risk difference
6.3
95% CI −6.9 to 19.2
P = 0.41
Events by treatment group
50th centile vs 5th centile
risk difference 6.3 (95% CI −6.9 to 19.2); P = 0.41
Secondary outcomes
Norepinephrine use
P = 0.04
ARDS prevalence · significantly higher in the 50th centile group
P = 0.02
| Outcome | 5th centile | 50th centile | P value |
|---|---|---|---|
| Vasoactive duration | 18.8 ± 10.8 | 30.4 ± 13.3 | P = 0.001 |
Vasoactive-Inotropic Score
- Vasoactive-Inotropic Score also higher (64.0 ± 35.7 vs. 45.2 ± 29.6)
- P = 0.001
LOS, ventilation duration, need for continuous renal replacement therapy (CRRT)
- No significant differences
Safety
Adverse events
- No significant differences
Original publication
Fifth Centile Versus 50th Centile Mean Blood Pressure Targets in Pediatric Septic Shock: A Randomized Controlled Trial. Crit Care Med. Published 5 August 2025. doi:10.
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