First evidence of a biomarker-based dose-response relationship in chronic pain using physiological closed-loop spinal cord stimulation
Authors' conclusion
Higher dose, more time over ECAP threshold, and higher accuracy are associated with better outcomes across patients.
Study context
- Population
- Patients with chronic pain treated with evoked compound action potential (ECAP)-controlled closed-loop spinal cord stimulation (SCS)over 600 SCS patients
- Outcome
- Relationship of neurophysiological metrics (therapy dose, usage above neural activation threshold, accuracy) with pain reduction
Main finding
As reported in the abstract
Objective neurophysiological metrics vs pain relief
- Significant relationships between objective metrics and pain relief, incl. first evidence of a dose-response relationship in SCS
- Higher dose, more time over ECAP threshold and higher accuracy associated with better outcomes
Observational data: associations, not effects.
Original publication
First evidence of a biomarker-based dose-response relationship in chronic pain using physiological closed-loop spinal cord stimulation. Reg Anesth Pain Med. Published 19 March 2024. doi:10.
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