Perioperative medicine & outcomes
Frailty and decisional regret after elective noncardiac surgery: a multicentre prospective cohort study
Authors' conclusion
Among older surgical patients, there appears to be a complex association with frailty and decisional regret, with substantial heterogeneity based on assumed causal pathways and surgery type.
Study context
- Population
- Patients aged ≥65 years undergoing elective noncardiac surgery
- Participants
- 669 patients
- Comparison
- Frailty vs no frailty
- Frailtyn = 293
- Primary endpoint
- Decisional regret about having undergone surgery (3-point ordinal scale)
- Follow-up
- 365 days
Methodological detailsBayesian ordinal logistic regression
- Bayesian ordinal logistic regression
Primary result
As reported in the abstract
Frailty vs No frailtyEstimate (95% CrI)
P(OR>1)=0.93; adjusted for surgery type, age, sex, mental health conditions
aOR 1.68(0.84–3.36)
P(OR>1)=0.97
OR (unadjusted) 2.21(0.98–5.09)
Further findings
Greater decisional regret at 30 and 90 days
- Similar results to 365 days
Greater decisional regret, additionally adjusted for baseline comorbidities and disability score (sensitivity analysis) · 365 days
- OR substantially altered
- 0.89
- 95% CrI
- 0.37-2.12
- P(OR>1)
- 0.39
Greater decisional regret, non-orthopaedic surgery (subgroup)
- OR
- 1.90
- 95% CrI
- 1.00-3.59
- P(OR>1)
- 0.98
- High probability that surgery type was an effect modifier
Greater decisional regret, orthopaedic surgery (subgroup)
- OR
- 0.87
- 95% CrI
- 0.41-1.91
- P(OR>1)
- 0.36
- High probability that surgery type was an effect modifier
Original publication
Frailty and decisional regret after elective noncardiac surgery: a multicentre prospective cohort study. Br J Anaesth. Published 3 September 2024. doi:10.
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