Gestational thrombocytopenia and risk of postpartum hemorrhage and severe maternal morbidity: a population-based analysis
Authors' conclusion
Gestational thrombocyoptenia is independently associated with higher odds of PPH, transfusion, and SMM.
Study context
- Population
- Deliveries in the New York State Inpatient Database (2016–2020)
- Participants
- 982,819 deliveries
- Exposure
- Gestational thrombocytopenia vs no gestational thrombocytopenia
- Gestational thrombocytopenian = 17,696
- Outcome
- Postpartum hemorrhage, blood transfusion, severe maternal morbidity (SMM) and non-transfusion SMM
Methodological detailspropensity-score matched (1:4), population-based
- Propensity-score matched (1:4)
- Population-based
Main finding
As reported in the abstract
PPH, transfusion, SMM, non-transfusion SMM
Gestational thrombocytopenia vs No gestational thrombocytopeniaOdds ratio (95% CI)
PPH
1.40(1.30–1.50)
Transfusion
1.57(1.42–1.73)
SMM
1.55(1.41–1.70)
Non-transfusion SMM
1.48(1.20–1.84)
- Prevalence of gestational thrombocytopenia
- 1.8%
Observational data: associations, not effects.
Further findings
| Outcome | OR |
|---|---|
| Transfusion and SMM, advantaged DCI cohort (subgroup)Gestational thrombocytopenia vs No gestational thrombocytopenia · transfusion · association most pronounced | 1.89 |
| Transfusion and SMM, advantaged DCI cohort (subgroup)Gestational thrombocytopenia vs No gestational thrombocytopenia · SMM · association most pronounced | 1.90 |
| Transfusion and SMM, Asian/Pacific Islander patients (subgroup)Gestational thrombocytopenia vs No gestational thrombocytopenia · transfusion · association most pronounced | 2.47 |
| Transfusion and SMM, Asian/Pacific Islander patients (subgroup)Gestational thrombocytopenia vs No gestational thrombocytopenia · SMM · association most pronounced | 2.42 |
By insurance status (subgroup)
- No significant differences by insurance status
Original publication
Gestational thrombocytopenia and risk of postpartum hemorrhage and severe maternal morbidity: a population-based analysis. Int J Obstet Anesth. Published 4 July 2026. doi:10.
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