Global estimates of prevalence of chronic painful neuropathy and moderate-to-severe neuropathy among patients with chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis of data from 29 countries between 2000 and 2024
An erratum to this article was published (Reg Anesth Pain Med, 5 Jan 2026 ↗)
Authors' conclusion
This study provides the first comprehensive global estimate of the prevalence of chronic moderate-to-severe CIPN or painful CIPN, highlighting its significant burden on patients worldwide.
Study context
- Population
- Patients diagnosed with chemotherapy-induced peripheral neuropathy (CIPN), 76 studies from 29 countries
- Participants
- 13,635 patients · 76 studies
- Outcome
- Pooled prevalence of chronic (≥3 months) moderate-to-severe CIPN or painful CIPN among patients with CIPN
Methodological detailsinverse variance heterogeneity model, double-arcsine transformation, subgroup analysis, metaregression
- Inverse variance heterogeneity model
- Double-arcsine transformation
- Subgroup analysis
- Metaregression
Pooled result
As reported in the abstract
Pooled prevalence of chronic moderate-to-severe or painful CIPN
Pooled prevalence
47.76%
95% CI 37.50 to 58.08
95% prediction interval
24.68-71.84
Heterogeneity I²
97.45%
Further pooled results
Prevalence by chemotherapy regimen (subgroup)
- Platinum-based agents
- 44.47%
- Taxanes
- 55.68%
Prevalence by primary cancer (subgroup)
- Breast cancer
- 61.31%
- Multiple myeloma
- 53.55%
- Lung cancer
- 50.85%
Metaregression: study design, human development index (HDI), publication year
- Non-significant moderators of prevalence estimates
Sensitivity analysis: studies explicitly measuring painful or moderate-to-severe CIPN
- Painful CIPN
- 40.78% (95% CI 29.08 to 52.74)
- Moderate-to-severe CIPN
- 49.04% (95% CI 37.16 to 60.95)
- Similar prevalence estimates
Original publication
Global estimates of prevalence of chronic painful neuropathy and moderate-to-severe neuropathy among patients with chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis of data from 29 countries between 2000 and 2024. Reg Anesth Pain Med. Published 29 January 2025. doi:10.
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