Neuroanesthesia & neurocritical care
Haemoglobin values, transfusion practices, and long-term outcomes in critically ill patients with traumatic brain injury: a secondary analysis of CENTER-TBI
Authors' conclusion
Anaemia was independently associated with long-term unfavourable neurological outcomes and mortality in critically ill TBI patients.
Study context
- Population
- Critically ill European traumatic brain injury (TBI) patients admitted to the Intensive Care Unit (ICU) with haemoglobin (Hb) data on admission and during the first week1,231 with admission Hb
- Participants
- 1,590 patients
- Comparison
- Daily lowest Hb < 7.5 g/dL or 7.5-9.5 g/dL vs > 9.5 g/dL during the first 7 days
- Primary endpoint
- Unfavourable Glasgow outcome scale extended (GOSE < 5)
- Follow-up
- 6 months
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Unfavourable neurological outcome (GOSE < 5) at 6 months, multivariable logistic regression · six months
Odds ratio (95% CI)
Increase of haemoglobin valuecontinuous; independently associated with decrease in unfavourable outcome
0.78(0.70–0.87)
< 7.5 g/dL vs > 9.5 g/dLlowest Hb within first 7 days
2.09(1.15–3.81)
7.5-9.5 g/dL vs > 9.5 g/dLlowest Hb within first 7 days
1.61(1.07–2.42)
Further findings
Mortality at 6 months
| OR (95% CI) | ||
|---|---|---|
| Increase of hemoglobin valueContinuous; associated with decrease of mortality | 0.88 (0.76–1.00) | |
| 0.512Odds ratio (log scale) |
| Outcome | OR (95% CI) | |
|---|---|---|
| Mortality at 6 months< 7.5 g/dL vs > 9.5 g/dL · Hb less than 7.5 g/dL associated with increase of mortality | 3.21 (1.59–6.49) | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Haemoglobin values, transfusion practices, and long-term outcomes in critically ill patients with traumatic brain injury: a secondary analysis of CENTER-TBI. Crit Care. Published 14 June 2024. doi:10.
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