Pediatric anesthesia & critical care
The Hemodynamic Effects of Protamine in Pediatric Patients Undergoing Pulmonary Artery Reconstruction and Unifocalization Surgery: A Pilot StudyHemodynamic Effects of Protamine in Children
Authors' conclusion
Protamine administration led to a small increase in PAP after separation from cardiopulmonary bypass in patients undergoing pulmonary artery reconstruction or unifocalization surgeries. Calcium coadministration did not lead to a greater increase in PAP.
Study context
- Population
- Pediatric patients undergoing pulmonary artery reconstruction or unifocalization surgery, large pediatric heart center in an academic quaternary care facility
- Exposure
- PAP after vs 2 minutes before protamine administration
- Outcome
- Change in PAP after protamine administration
Methodological detailspilot study, single-centre
- Pilot study
- Single-centre
Main finding
As reported in the abstract
PAP
29.00 mmHg versus 25.00 mmHg mmHg
P < 0.001
2 minutes vs 2 minutes before · PAP higher at 2 minutes after protamine
PAP
30.00 mmHg versus 25.00 mmHg mmHg
P < 0.001
5 minutes vs 2 minutes before · PAP higher at 5 minutes after protamine
PAP
31 mmHg versus 25 mmHg mmHg
P < 0.001
10 minutes vs 2 minutes before · PAP higher at 10 minutes after protamine
- Difference in PAP after protamine bolus (Friedman χ2)
- 49.46
Observational data: associations, not effects.
Secondary outcomes
| Outcome | PAP (mmHg) | P value |
|---|---|---|
| PAP with calcium coadministration10 minutes after calcium administration vs 2 minutes before · higher PAP 10 minutes after calcium | 32 mmHg versus 26 mmHg | P < 0.001 |
- PAP with calcium coadministration — Significant increase in PAP with calcium coadministration (Friedman χ2)
- 28.11
- PAP with calcium coadministration: Friedman χ2 = 28.11; p < 0.001
Original publication
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