Neuroanesthesia & neurocritical care
Hemoglobin Concentration Impacts Viscoelastic Hemostatic Assays in ICU Admitted Patients*
Authors' conclusion
Lower hemoglobin concentrations have a consistent, measurable impact on ROTEM/TEG testing in ICU admitted patients, which appear to be artifactual.
Study context
- Population
- Intracerebral hemorrhage (ICH) and perioperative patients admitted to tertiary referral ICUs
- Participants
- 34 / 239 / 121
- Exposure
- Rotational thromboelastometry (ROTEM) ICH vs thromboelastography (TEG) ICH vs Perioperative ICU
- ROTEM ICHn = 34
- TEG ICHn = 239
- Perioperative ICUn = 121
- Outcome
- Relationship of baseline hemoglobin with ROTEM/TEG results (Spearman correlations, linear regression)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Correlation of hemoglobin with viscoelastic parameters
| Group | R, coagulation kinetics | p, coagulation kinetics | R, clot strength | p, clot strength |
|---|---|---|---|---|
| ROTEM ICH | 0.46 | p = 0.01 | −0.52 | p = 0.002 |
| TEG ICH | 0.49 | p < 0.0001 | −0.40 | p < 0.0001 |
R, coagulation kinetics
ROTEM ICH0.46
TEG ICH0.49
p, coagulation kinetics
ROTEM ICHp = 0.01
TEG ICHp < 0.0001
R, clot strength
ROTEM ICH−0.52
TEG ICH−0.40
p, clot strength
ROTEM ICHp = 0.002
TEG ICHp < 0.0001
Observational data: associations, not effects.
Further findings
Perioperative ICU cohort
- Similar relationships identified
Linear regression models
- Relationships persisted
In vitro hemoglobin lowering of ICH blood samples (ROTEM)
- Lower hemoglobin resulted in progressively faster coagulation kinetics and greater clot strength
Original publication
Hemoglobin Concentration Impacts Viscoelastic Hemostatic Assays in ICU Admitted Patients*. Crit Care Med. Published 3 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →