High dose dexamethasone in high pain responders undergoing total hip arthroplasty: A randomized controlled trial
Primary result · VAS >30 mm in the 5-m walk testResult — go to the resultRelative risk 1.04 95% CI 0.72–1.51Authors' conclusion
1 mg kg -1vs. 0.3 mg kg -1 dexamethasone improved neither postoperative pain nor recovery in THA in a cohort of predicted high pain responders.
Study context
- Population
- Patients undergoing total hip arthroplasty (THA) by neuraxial block with multimodal analgesia, Pain Catastrophising Scale score >20 and/or preoperative opioid use (predicted high pain responders), Denmark
- Participants
- 160 patients
- Comparison
- Dexamethasone 1 mg kg −1 vs 0.3 mg kg −1 before THA
- Primary endpoint
- Proportion with moderate to severe pain (VAS > 30 mm on 0 to 100 mm scale) on ambulating
- Follow-up
- 24 h after surgery
Methodological detailsdouble-blind, two-centre, Two large arthroplasty sites in Denmark, February 2019 to August 2020
- Double-blind
- Two-centre
- Two large arthroplasty sites in Denmark, February 2019 to August 2020
Primary result
VAS >30 mm in the 5-m walk test
Relative risk
1.04
95% CI 0.72–1.51
P = 0.814
Events by treatment group
1 mg kg −1 vs 0.3 mg kg −1
RR 1.04 (95% CI 0.72–1.51); P = 0.814
As reported in the abstract
Secondary outcomes
C-reactive protein (CRP) and opioid use
- No differences between groups
Recovery scores and re-admissions
- No intergroup differences
Safety
Complications
- No intergroup differences
Original publication
High dose dexamethasone in high pain responders undergoing total hip arthroplasty: A randomized controlled trial. Eur J Anaesthesiol. Published 11 May 2023. doi:10.
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