Histopathological patterns of hypoxic-ischemic encephalopathy after cardiac arrest: A retrospective brain autopsy study of 319 patients
Authors' conclusion
CA causes typical histopathological HIE patterns, with the hippocampus being more susceptible to SEND, than the cerebral neocortex, and the brainstem being the most resistant brain region. The neocortical distribution of SEND is mostly homogeneous; however, a relevant subgroup shows substantial neocortical HIE heterogeneity.
Study context
- Population
- Cardiac arrest (CA) patients with initially successful resuscitation who received brain autopsies after death
- Participants
- 319 patients
- Outcome
- Selective eosinophilic neuronal death (SEND) in neocortex, hippocampus, basal ganglia, cerebellum and brainstem; histopathological HIE patterns
Methodological detailsmonocentric
- Monocentric
Main finding
As reported in the abstract
Mean selective eosinophilic neuronal death (SEND), hippocampus
1.8
Mean SEND, neocortex
1.4
Mean SEND, brainstem
0.9
Observational data: associations, not effects.
Further findings
Neocortical heterogeneity: SEND differing by >30% between two neocortical regions (72 patients with 2 regions)
- SEND differed by >30%
- 7(9.7%)
Predominant SEND region among 154 patients with SEND >30% in ≥1 region
- Predominant SEND in cerebellum
- 14(9.1%)
- Predominant SEND in basal ganglia
- 4(2.6%)
Original publication
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